Bluebrim Bioscience’s Bioanalytical Blueprint

Services and Solutions Tailored for You and Your Drugs!

Method Development

Employing analytical method development and validation, we create selective and specific methods and assays that respond to You and Your Project the best!

There is no one set standard for every drug.

We raise our standards for each and every client and their drugs!

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Optimization

There is no limit to how effective and efficient our methods and assays can become.

We optimize sample collection.
We optimize sample preservation.
We optimize sample preparation.

Stirred and concocted together, we optimize analytical sensitivity without compromising selectivity.

We don’t settle for anything but the best!

A laptop with a sea blue screen, and on the screen is four connected nodes, rising upwards slowly. This represents our optimization process, ever approaching a better and more perfect solution.

Validation

Adhering to Good Clinical Practice and Good Laboratory Practice guidelines, we perform partial and full method validation.

We invoke all quality control and quality assurance measures, ensuring the integrity and reliability of our data.

We review and update our methods over and over, until we get it perfect!

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PK and PD, Biodistribution, Clearance, ADME

What is pharmacokinetics? What is pharmacodynamics?

Pharmacokinetics vs Pharmacodynamics?

Pharmacokinetics describes how a drug moves through the human body, and it includes Absorption, Distribution, Metabolism and Excretion (ADME).

Pharmacodynamics describe the human body’s response to a drug, from a biological, physiological and molecular perspective.

Biodistribution studies determine how a drug might transfer to other parts of the body, intended and unintended. Clearance measures the rate at which a drug exits the blood. Both provide valuable insight on how to best maximize a drug’s positive effects and minimize its negative effects.

The collaboration of PK and PD studies is foundational to a drug’s success — mirroring the collaborative partnership between CRO and pharmaceutical.

Our client-centric approach privileges our partnership, with an emphasis on communication and collaboration.

Large Molecule Bioanalysis (Biologics)

Small Molecule Bioanalysis

Nucleic Acid Therapeutics

Gene Therapy & Gene Editing

Oncolytic Viruses

Microbiome

Large Molecule Bioanalysis (Biologics) Small Molecule Bioanalysis Nucleic Acid Therapeutics Gene Therapy & Gene Editing Oncolytic Viruses Microbiome

Large Molecule Bioanalysis (Biologics)

Small Molecule Bioanalysis

Nucleic Acid Therapeutics

Gene Therapy & Gene Editing

Oncolytic Viruses

Microbiome

Large Molecule Bioanalysis (Biologics) Small Molecule Bioanalysis Nucleic Acid Therapeutics Gene Therapy & Gene Editing Oncolytic Viruses Microbiome

Biomarker Testing

What are biomarkers?

Biomarkers provide measurable indicators of biological processes and responses, which can used to assess the safety and efficacy of potential drugs. From early discovery to post-marketing surveillance, biomarkers are critical to drug research, design and development.

Which is exactly why You need a trustworthy, timely and dedicated partner for biomarker analysis.

Trust the Science. Trust Bluebrim.

We utilize a wide range of methods to measure biomarkers, including (but not limited to):

ELISA, qPCR/RT-qPCR, NGS, GWAS, LC-MS/MS Mass Spectrometry, MSD, Flow Cytometry, Immunofluorescence (IF)

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Immunogenicity Testing

Will your drug stimulate immune responses? If yes, are those the desired responses? If no, why not?

When it comes to all things immune system, we are the premier experts. We monitor and manage immunogenicity, controlling it to get You and Your Drug the desired responses (or none at all), all while ensuring safety, efficacy and most of all, success!

Here are our immunogenicity assays and methods:

Anti-Drug Antibody (ADA) Detection: ELISA, ECL, MSD, SPR, Western Blotting, Protein Microarray

Cellular Immune Response Analysis: Lymphocyte Proliferation, Cytokine Release (MSD, multiplex), ELISpot Assays, Intracellular Cytokine Staining (ICS) via Flow Cytometry, Tetramer Staining

Neutralizing Antibody Assays (NAb): Cell-Based Assays and Viral Assays

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Toxicology Studies

What is toxicology?

Toxicology aims to evaluate the safety and potential adverse effects of a drug candidate in various biological systems, from rats to humans.

We have no time for toxic chemicals and reagents, just as You have no time for toxic drugs. We protect Your Drug from failure and deliver an improved version of it — Our Bluebrim Guarantee!

We monitor and measure the quantitative concentration of a drug and its metabolites, assess its toxicological profile and detect toxic biomarkers. We offer:

Toxicokinetic Studies, Metabolite Profiling, Biomarker Analysis, Drug-Drug Interaction Studies, Tissue Distribution Studies

A scientist looking through a microscope at a cell plate.

Cellular Biology
Molecular Biology

Proteomics
Genomics

Cellular & Molecular Proteomics Genomics
Cell Culture Protein Identification DNA/RNA Extraction & Quantification
Mammalian Cell Culture Mass Spectrometry-Based Identification cDNA Synthesis
Cell Visibility & Cytotoxicity Assays De Novo Sequencing Gene Expression Analysis
Cell Proliferation Assays Label-Free Quantification Genotyping
Cell Cycle Analysis Isotopic Labeling (SILAC, iTRAQ) DNA Sequencing
Apoptosis & Necrosis Detection 2D Gel Electrophoresis Vector Construction & Cloning
Fluorescence-Activated Cell Sorting (FACS) Western Blotting CRISPR-Cas9 Genome Editing
Live Cell Imaging Protein-Protein Interaction Methylation Analysis
Cell Migration & Invasion Assays Immunoprecipitaton Chromatin Immunoprecipitation (ChIP)
Stem Cell Culture & Differentitation Protein Purification Transcriptomics
Metabolic Assays
Functional Assays (GPCR, Ion Channel, etc.)

Custom Assays and Services

Don’t quite see what you’re looking for? Do you require assays and/or services which aren’t listed above or in our catalog?

Worry Not — Bluebrim Bioscience has You Covered!
You Request It — We Deliver!

Whatever your request, whatever challenges our standard services can’t cover, we can develop, optimize and validate new assays to meet the demand. We have the experience and expertise for even the most challenging of projects.

Examples:

Assay Development and Validation

Matrix-Specific, Species-Specific, Multiplex, Customizable Biomarkers, Non-Routine Samples

Method Transfer and Optimization

Transfer methods to a new lab, Optimize methods to enhance sensitivity, specificity and efficiency

And More. . .

All Awaiting Your Request!